الفهرس 
I NFANT OF DIABETIC MOTHEROnly 14 pages are availabe for public view
 |  | from | 146 |  |  |
| | | from | 146 | | |
Abstract
Background: Oxidative stress can play an important role in the pathogenesis of diabetes mellitus (DM), gestational DM and in the development of maternal and fetal complications of diabetic pregnancies. Ischemia modified albumin (IMA) is an altered type of serum albumin that forms under conditions of oxidative stress and is used as an early marker in several pathological conditions including diabetes. Aim: To determine the levels of IMA in infants of diabetic mothers as a marker of oxidative stress and to assess its relation to clinical and laboratory characteristics including lipid peroxidation, total anti-oxidant status, essential trace elements and maternal glycemic control. Methods: This study was conducted on 100 full term neonates delivered at Obstetrics and Gynecology hospital, Ain Shams University; 50 infants were born to diabetic mothers and another 50 age- and sex-matched healthy infants were enrolled as controls. Maternal laboratory investigations included random blood glucose (RBG) and HbA1c. Total antioxidant capacity (TAC), malondialdehyde (MDA), IMA and trace elements (copper, zinc and iron) were measured in cord blood. Results: TAC, copper and zinc were significantly lower while MDA, IMA and iron levels were higher among infants of diabetic mothers than control group. Low TAC levels were found among diabetic mothers on diet without insulin therapy compared with those on insulin therapy. Maternal HbA1c were negatively correlated to TAC while positively correlated with MDA and IMA. IMA was positively correlated to maternal RBG and HbA1c while there were negative correlations between IMA and each of TAC and copper. Conclusions: Oxidative stress is enhanced in infants of diabetic mothers as manifested by increased lipid peroxidation and IMA levels. IMA could be useful for detecting the potential oxidative stress among those infants. Increased oxidative stress is accompanied by alterations in the antioxidant defense status. Changes in oxidant-antioxidant balance in infants of diabetic mothers are related to maternal blood glucose and glycemic control. Proper metabolic control among diabetic mothers is mandatory to avoid oxidative stress and its potential harmful effects among their infants.