الفهرس 
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Abstract
Jaundice is the most common clinical sign in neonatal medicine.
About 60% of healthy term infants and 80% of premature infants develop
clinically visible jaundice in the first week of life. In the majority of
cases, jaundice is mild and transient, resulting from an immaturity of the
liver’s excretory pathway for bilirubin . Neonatal jaundice remains one of
the most common reasons for readmission to hospital in the first week of
life.
Jaundice is the yellowish pigmentation of the skin, sclera, and mucous
membranes resulting from bilirubin deposition. Jaundice can be
physiological or pathological.
Vitamin D is a steroidal prohormone, the active type which plays a
significant role in absorption of calcium and phosphate. It reaches the
body through skin synthesis via ultraviolet rays when the sun exposure is
adequate and can be ingested through food. Through influencing the
absorption of calcium in the intestinal tissues and other effects on bone
and other tissues of the body, the metabolites of this vitamin have key
roles in regulating the metabolism of minerals.
The aim of this work was to estimate the serum levels of vitamin D in
jaundiced and non-jaundiced healthy full-term neonates.
The present study included 50 neonates that have been classified into
two groups:
group I: 25 jaundiced healthy full-term neonates with with
physiological jaundice as the patient group.
group II: 25 non-jaundiced healthy full-term neonates as the control
group.
Both patients and controls in the study have been subjected to history
taking, complete clinical examination and routine laboratory
investigations for neonates including WBCs, reticulocytes, serum
calcium,magnesium, phosphorus, total bilirubin ,direct bilirubin and CRP
in addition to abdominal ultrasonography and chest x-ray.
Serum vitamin D samples were withdrawn from all neonates at
admission with age ranging from 3 to 10 days.
Our results showed that:
In patient group:
- Significant negative correlation between neonatal vitamin D level
and maternal age.
- Significant negative correlation between neonatal vitamin D level
and maternal BMI.
- Highly Significant negative correlation between neonatal vitamin
D level and TSB.
- Significant negative correlation between neonatal vitamin D level
and DSB.
- Non-significant correlation (P >0.05) between neonatal vitamin D
level and birth weight.
- Non-significant correlation (P >0.05) between neonatal vitamin D
level and gestational age.
- Non-significant correlation (P >0.05) between neonatal vitamin D
level and postnatal age.
- Non-significant correlation (P >0.05) between neonatal vitamin D
level and CRP.
In control group: - Highly negative correlation, between neonatal vitamin D level with maternal age. - Significant negative correlation, between neonatal vitamin D level with maternal BMI. - Highly negative correlation, between neonatal vitamin D level with TSB. In the end, there was highly statistically significant difference in the serum 25-hydroxy vitamin D levels between newborns with hyperbilirubinaemia and control group (p=0.004). Our results suggest that low level of serum vitamin D may associate with hyperbilirubinaemia in full-term neonates in negative correlation between them.