الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Our study was aimed to study the adverse effects of Aflatoxins on performances, immunity, some biochemical parameters in serum and tissues of Japanese quails as well as to evaluate the possible protective effects of Nigella sativa crushed seeds and curcumin powders against the adverse effects of Aflatoxins. A total 120 unsexed Japanese quails chicks were equally divided into 4 groups; control group (G1), Aflatoxins group 2.5 ppm (G2), Aflatoxins 2.5 ppm plus Nigella sativa 1.5% of diet (G3) and Aflatoxins 2.5 ppm plus curcumin powders 400 mg/kg diet (G4) for one month of experiment. Aflatoxins induced hepatotoxicity and immunosuppressive revealed significance decrease in total protein, Albumin and globulin, on the other hand significantly increased in total cholesterol, triacyglycerol, but significance decrease in HDL-c, although Aflatoxins induced a significance increase in LDL-C, significance increase in alanine aminotransferase (ALT) and Aspartate aminotransferase (AST),significally increased in creatinine and uric acid level, significantly decreased in SOD, GSH, CAT and significantly increased in MDA, significance increase in Aflatoxin residues in liver tissues and DNA fragmentation percentage in liver tissues on 1% Agarose Gel Electrophoresis, decrease B.W, total Leucocytic count , lymophcyte percent, oesenophil percent and monocytes percent, while increase in neutrophil percent and basophil percent, and considerable histopathological damage in liver and kidney. Treatment with Nigella sativa and curcumin induced significantly increased in TP, Albumin and globulin, on the other hand significantly decreased in total cholesterol, triacylglycerol and LDL-c, while induced significance increase in HDL-c, although Nigella sativa and curcumin groups showed a significance decrease in ALT and AST, significance increase in creatinine and uric acid level, significantly increased in SOD, GSH, CAT and significantly decreased in MDA, also a significance reduction in Aflatoxins residues in liver tissues and DNA fragmentation on 1% Agarose Gel Electrophoresis in liver tissue. Treatment with Nigella sativa and curcumin produce significantly increased in B.W, TLC , lymophcyte %, oesenophil % and monocytes %, while decrease in neutrophil % and basophil %. This study indicated that treatment with Nigella sativa and Curcumin improved the adverse effects of Aflatoxins on performances, immunity, some biochemical parameters in serum and tissues, more protection for DNA from fragmentation which have been supported by the liver and kidney histopahology.