الفهرس 
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Abstract
Although osteoarthritis (OA) is one of the most prevalent musculoskeletal diseases in the world, its treatment is still relatively limited. There is little evidence that the currently used drugs have effective action against the progression of the disease
The majority of patients does not show significant improvement when treated with conservative measures which includes; reassurance, physiotherapy, non-steroidal anti-inflammatory drugs (NSAID), local corticosteroid injection or case immobilization. SO A relatively new strategy for the treatment of OA should be carried out.
A relatively new era for the treatment of OA is the use of cell elements and biomediators of tissue response. In this study, the platelet-rich plasma (PRP) has been configured as a perspective for improving clinical and structural outcomes by delivering a high concentration of growth factors that mediate cartilage healing and remodeling. Thus, this study has the purpose to present a review of its use in knee osteoarthritis.
In our study, we aimed to evaluate the clinical outcome of PRP injection after arthroscopic debridement in knee osteoarthritic patients.
Twenty patients with 20 knees whom included in this study were diagnosed to have primary knee OA for at least 6 months before the procedure with failure of conservative treatment to control pain.
For all patients, conventional radiographs of the knee were done in two planes to rule out fracture, tumor, and infection. The KNEE SOCIETY SCORING SYSTEM for evaluating results of procedure pre and post-operatively. Patients were followed-up for at least 6 months after the injection procedure.
As regards our results in this study; we concluded that; PRP injection after arthroscopic debridement appears to have a potential for improving knee function and quality of life of patients suffering from primary knee OA, by means of reducing the pain and, in a lesser extent, the degenerative articular processes. Nevertheless, some suggestions can be proposed; indeed, a better result seems to be related to younger patients, lower grades of OA, low BMI and short-term follow-up (the median duration of the efficacy of PRP injections being estimated at 9 months.)
The Longer follow-up would be beneficial to determine whether there is an endpoint of benefit from this procedure. Perhaps, another series of injections would benefit those who did not receive a favorable outcome or reached a plateau with time. The study included a range of patients with varying degree of OA both anatomically and functionally, which could perhaps explain the variation of overall satisfaction.