الفهرس 
Laryngeal CancerOnly 14 pages are availabe for public view
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Abstract
The study was aiming to investigate the mutations of human 8-
Oxoguanine DNA N-Glycosylase 1 gene in cancer larynx through a case
control study conducted on 20 patients of cancer larynx (group Ι) and 10
apparently healthy control subjects (group ΙΙ).
Complete history, clinical examination and routine laboratory
investigations (C.B.C, ESR, LFT and KFT) were performed. Genotyping of
the hOGG1 gene was performed by PCR/RFLP.
Our study revealed:
- No statistical significant difference between patients (group Ι) and
healthy controls (group ΙΙ) of cancer larynx as regard age, sex and
CBC.
- A statistical significant difference between patients (group Ι) and
healthy controls (group ΙΙ) of cancer larynx as regard smoking and
ESR.
- A statistical significant difference between patients (group Ι) and
healthy controls (group ΙΙ) of cancer larynx as regard Ser/Ser and
(Ser/Ser + Ser/Cys) genotypes.
- No statistical significant difference between patients (group Ι) and
healthy controls (group ΙΙ) of cancer larynx as regard Ser/Cys and
Cys/Cys genotypes.
- No statistical significant difference between patients (group Ι) and
healthy controls (group ΙΙ) of cancer larynx in hOGG1 genotypes as
regard the degree of smoking.
from this study it could be concluded that the ser/cys and cys/cys
genotypes of the hOGG1 DNA repair gene may play a role in thedevelopment of cancer larynx.