الفهرس 
History of LymphomaOnly 14 pages are availabe for public view
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Abstract
Background/ aim: There are two major types of lymphoma: Hodgkin’s lymphoma and non- Hodgkin’s lymphoma. Hodgkin’s lymphoma (HL) tends to affect younger patients and be relatively curable, whereas non- Hodgkin’s lymphoma (NHL) tends to affect older patients and carry a worse long-term prognosis as a group. Antioxidants are molecules that can neutralize free radicals by accepting or donating an electron to eliminate the unpaired condition. One of these antioxidant molecules was reduced glutathione (GSH) that can reduce free radicals by hydrogen donation. Also, superoxide dismutase (SOD) is one of the most important natural antioxidant enzymes manufactured in the body provide an important defense against free radicals, that converts two superoxide radicals into one hydrogen peroxide and one oxygen. Malondialdehyde (MDA), the end product of lipid peroxidation (LPO), arising from the free radical degradation of polyunsaturated fatty acids, can cause cross-linking in lipids, proteins and nucleic acids. Our study aimed to detection of GSH, SOD and MDA as prognostic biomarkers associated with lymphoma patients in a population from Damietta, Egypt. Material and method: This hospital-based case-control study was conducted during (2007-2010); 50 lymphoma cases and 14 controls were enrolled. Information was collected and blood samples were obtained and parameters were determined by standard techniques. Associations between variables of interest and non-Hodgkin, Hodgkin Lymphoma(NHL, HL) were assessed using conditional logistic regression. Results: We found that at initial diagnosis of NHL patients, GSH was negative for all patients (100%) and remain negative after treatment applied with cut-off value (2.09 m Mol/L cells). Also, SOD was negative for all patients (94.3%) before treatment applied except two cases ( 5.7%) were positive. It still negative (100%) after treatment applied with cut-off value (33.95%). On the other hand, MDA was positive for patients (94.3%) and negative for patients (5.71%). Then, it was positive for patients (73.7%) and negative for patients (26.3%) after treatment applied with cut-off value (0.53 X10 Mole / mL packed cells). On the other side, at initial diagnosis of HL, GSH was negative for all patients (100%) and remain negative after treatment applied with cut-off value (2.09 m Mole/L cells). Also, SOD was negative for patients (93.3%) before treatment applied except one case ( 6.7%). It still negative (100%) after treatment applied with cut-off value (33.95%). On the other hand, MDA was positive for patients (100%). Then, it became positive for patients (83.3%) and negative for patients (16.7%) after treatment applied with cut-off value (0.53 X 10 Mole / mL packed cells). Conclusion: These findings suggest that MDA level was elevated in NHL and HL patients, before and after treatment on comparison to that of controls. But SOD, GSH levels were decreased before and after treatment at all.