الفهرس 
INTRODUCTION AND RATIONALEOnly 14 pages are availabe for public view
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Abstract
CAD is the leading cause of mortality worldwide. It has a multifactorial etiology involving physiological, environmental and genetic factors. Among genetic factors, the gene encoding PON1 has been implicated in conferring genetic susceptibility to CAD.
It has been shown that PON1 has its protective role in atherogenesis: it protects LDL, HDL and macrophages against oxidative stress. Moreover, PON1 preserves the integrity of HDL and is responsible for its anti-oxidative and anti-inflammatory effects. These findings led to the suggestion that PON1 activity has a role in susceptibility to atherosclerotic disease.
PON1 gene is located on chromosome 7q21.3, among several genetic aberrations, the Q192R (rs662) polymorphism in the coding region of PON1 gene that results in a glutamine (Q) to arginine (R) (A/G) substitution at position 192 was widely studied. The catalytic activity of PON1 is greatly affected by amino acid substitutions at position 192.