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Abstract The vaccination campaign (using live Smith burn virus vaccine) performed in Egypt during the outbreaks of 1996,1997 and 2003 did not stop the disease but it causes viremia in vaccinated animals which explain the fear of spread of the virus via mosquito’s vectors and the concern possible reassortment event with wild type viruses. The Egyptian GOVS in the 2008 demonstrated that (Rift Valley Fever) live vaccine (Smith burn strain) isn’t used in Arab Republic of Egypt in the present time. Consequently, the RVF vaccination programs in Egypt are performed by inactivated (ZH-501) RVF vaccine. In this study Inactivated smith burn RVF vaccine was prepared and evaluated by serological tests (SNT and ELISA), compared with local vaccine. Results indicated that inactivated Smith burn RVF vaccine was more protective, induced high titer of antibodies. Furthermore, time of protection is longer than the local vaccine. |