الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Wound healing is usually a highly successful biological process to restore the integrity of the skin following injury. The mechanisms of wound healing typically fall along a spectrum between tissue regeneration, the end result of which would be functionally equivalent to the uninjured skin, and tissue repair, during which the skin’s functional characteristics are sacrificed in favor of rapidly closing the wound with fibrotic scar tissue. Scars are an undesirable consequence of cutaneous wound healing not only because of their appearance but because of their poor mechanical strength relative to the surrounding tissue. Substantial dysregulation of wound healing can result in a nonhealing wound or ulcer, as frequently observed in diabetic individuals because of their microvascular deficiencies. As a result, the annual worldwide market for advanced wound care products to promote healing in hard-to-heal wounds and to reduce the appearance of scars exceeds $5 billion.
The cell source used in cellular therapies for wound healing is an important consideration that has implications in the cost, speed, and outcome of the treatments. Human keratinocytes are perhaps the optimal cell type to employ as they make up the epidermal zone of skin tissue. However, autologous and allogeneic keratinocytes suffer from the same drawbacks as their autologous and allogeneic skin graft counterparts, i.e., secondary surgical sites and potential for rejection, respectively.
Wound healing requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Central to this process is the endogenous mesenchymal stem cell (MSC), which coordinates the repair response by recruiting other host cells and
secreting growth factors and matrix proteins. MSCs are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, cartilage, tendon, and fat. In addition to multilineage differentiation capacity, MSCs regulate immune response and inflammation and possess powerful tissue protective and reparative mechanisms, making these cells attractive for treatment of different diseases. The beneficial effect of exogenous MSCs on wound healing was observed in a variety of animal models and in reported clinical cases. Specifically, they have been successfully used to treat chronic wounds and stimulate stalled healing processes. Recent studies revealed that human placental membranes are a rich source of MSCs for tissue regeneration and repair. This study provides a concise summary of current knowledge of biological properties of MSCs and describes the use of MSCs for wound healing. In particular, the scope of this study focuses on the role MSCs have in each phase of the wound-healing process. In addition, characterization of MSCs containing skin substitutes is described, demonstrating the presence of key growth factors and cytokines uniquely suited to aid in wound repair.
In this study 100 women (primigravida, fullterm and indicated for cs ) were observed for their wound healing after 7 days of cs divided into 2 groups :1- case group (50 women) using placental membrane as a source of MSCS as dressing for their caesarean incision.
Control group (50 women) using traditional dressing for their caesarean incision.
Results of this study revealed that there is significant difference in wound healing outcome between cases and control groups.