الفهرس 
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Abstract
This work was carried out at the Nutrition and Veterinary Clinical Nutrition Department, Faculty of Veterinary Medicine, Alexandria University to investigate the effect of chemical or biological mycotoxin adsorbent on growth performance, immune response, some blood biochemical changes and some carcass traits of broiler chicken. A total of 210 one-day-old dual purpose chicks of mixed sex were used in this experiment. They were obtained from a local Egyptian private hatchery. The chicks were randomly allotted into 6 equal groups (35 chicks/group). First group fed on the basal diet without any supplementation and considered as control, while groups 2 – 3 fed on the same basal diet with chemical (Detox 1ml/liter) (Based on organic acids) and biological (Ochramat 0.5ml/liter) (Based on yeast, glucomannan, plant extract and enzymes) mycotoxin binder supplementation through drinking water respectively, while group 4 – 6 fed as mentioned for the first three groups with aflatoxin B1 (AFB1) contamination from 21th days of broiler age at a rate of 1mg of AFB1/Kg diet. The obtained results summarized in the following: It was observed that chemical or biological mycotocin binder supplementation significantly (P≤0.05) improved final body weight, body weight gain, feed efficiency feed conversion ratio, feed intake, protein intake and its utilization, energy intake and its utilization when compared with broiler chicken fed on the basal diet without supplement.It was found that aflatoxin feed contamination without mycotoxin binder supplementation significantly (P≤0.05) reduced final body weight by about 5.4% compared with broiler chicken group fed on the same diet without aflatoxin B1 contamination. On the other hand, chemical or biological mycotoxin binder supplementation with aflatoxin B1 contamination counteract the deleterious effect of aflatoxin B1 and significantly (P≤0.05) improved final body weight by about 23.3% and 19.6% respectively compared with broiler chicken fed on the contaminated diet without mycotoxin binder supplementation. It was observed that, AFB1 feed contamination without mycotoxin binder supplementation significantly (P≤0.05) reduced total weight gain throughout the whole experimental period by about 5.6% when compared with broiler chick group fed on the basal diet without AFB1 contamination. Moreover, chemical (based on organic acid) or biological (based on yeast cell wall, beta-glucan and enzyme) mycotoxin binder supplementation with AFB1 feed contamination significantly alleviated the effect of AFB1 and improved weight gain and has shown the best body weight among all treatments.
• it was observed that chemical or biological mycotoxin binder supplementation with AFB1 contamination slightly reduced total feed intake compared with broiler chicken group fed on the same mycotoxin binder without AFB1 contamination. It was observed that AFB1 feed contamination significantly (P≤0.05) reduced average PI throughout the whole experimental period by about 12.55% compared with control one which fed on the basal diet without AFB1 contamination. Moreover, chemical or biological mycotoxin binder supplementation with AFB1 feed contamination improve PI to nearly the normal values. The carcass characters as net weight and dressing percentage improved with mycotoxin binder supplementation compared with broiler chicken fed on the basal diet without supplement. The level of WBCs, RBCs, , Hb %m calcium, phosphorus, cellular immunity as lymphocytes and neutrophils as well as serum albumin of the broilers improved with mycotoxin binder supplementation compared with broiler chicken fed on the basal diet without supplement. The cholesterol, fat, urea uric acid and creatinine as well as serum enzymes level decreased with mycotoxin binder supplementation compared with broiler chicken fed on the basal diet without supplement. Phagocytic activity and index improved with mycotoxin binder supplementation compared with broiler chicken fed on the basal diet without supplement. The bird immunity against some diseases as Newcastle diseases improved with mycotoxin binder supplementation compared with broiler chicken fed on the basal diet without supplement. The lymphoid organs weight and relative weight of the internal organs improved with mycotoxin binder supplementation compared with broiler chicken fed on the basal diet without supplement. Among other treatments, AFB1 level was the highest in group fed on the basal diet with feed AFB1 contamination (14.5 ppb). Compared to broiler chicks group fed on AFB1 contaminated diet without supplement, supplementing chemical or biological mycotoxin binder to drinking water markedly reduced the AFB1 concentration by about 68.3% and 77.2% respectively. It was observed that chemical or biological mycotoin binder supplementation significantly (P≤0.05) increased AFB1 in the ileal and cecal content by about (325.5% and 211.4%) and (470.8% and 258.2%) respectively compared with broiler chicks group fed on AFB1 feed contamination without supplementation. The study cleared that, the feeding broilers feed contaminated with AFB1 reduces the productive performance characters of the broilers and reduce its productivity. While, the addition of mycotoxin binder supplementation (Detox 1ml/liter & Ochramat 0.5ml/liter) improve the productive performance parameters of the broilers. Also our results cleared that, the biological mycotoxin binder supplementation (Ochramat 0.5ml/liter) improved the productive performance characters of the broilers than the addition of chemical mycotoxin binder supplementation (Detox 1ml/liter).