الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Dental erosion is recognized as an important cause of tooth structure loss, not only in adults, but also in children and adolescents. It is defined as the irreversible loss of dental hard tissue due to a chemical process of acid dissolution that does not involve bacterial plaque acid, and is not directly associated with mechanical or traumatic factors. Dental erosion is caused by exposure to acidic substances from varieties of sources, either of an intrinsic or an extrinsic source. Several cases of tooth erosion have been attributed to oral administration of liquid oral medications. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) has developed a great concern in modern dentistry for having anti- erosive properties. Under acidic conditions, CPP-ACP binds readily to the surface of the tooth and the casein derived phophopeptides, buffers free calcium and phosphate ions and deposits a high concentration of ACP clusters in close proximity to the tooth surface. In a consequence, that will raise calcium and phosphate level in plaque maintaining a state of super saturation, inhibiting demineralization and enhancing remineralization. So this study aimed to evaluate the remineralizing capacity of casein phosphopeptide amorphous calcium phosphate CPP-ACP on erosive lesions induced by antihistaminic syrup on enamel of primary teeth and determine the effectiveness of CPP-ACP in reducing further erosion by antihistaminic syrup.
Twenty exfoliated primary teeth were sectioned in a buccolingual direction into two halves, one served as a control specimen and the other served as a study specimen. Specimens of both groups were immersed in antihistamine syrup for 30 min twice daily for 12 days to produce erosive enamel lesions. Study group specimens were treated with the remineralizing agent CPP-ACP once daily 3min for 10 consecutive days and the control group specimens remained untreated. Then, the treated specimens were subjected to a second erosive challenge. Specimens were evaluated for their surface microhardness by using Vickers microhardness testing and their surface quality by using SEM.
Results revealed that the antihistamine syrup decrease the surface microhardness of teeth specimens significantly. Treatment of study group specimens with CPP-ACP Paste increased their surface microhardness significantly. Further re-erosion of the study group specimens with antihistamine syrup decreased their surface microhardness significantly.
Micrographs of scanning electron microscope were consistent with the results of surface microhardness. Micrographs of eroded specimens showed a severe eroded pattern with significant structural loss and crater formation but that of treated specimens showed normal appearance of enamel with smaller, less mineralized enamel structure. As to the micrographs of re-eroded study specimens, it showed smaller areas of normal enamel with less mineralized areas, other areas of structural loss and enamel cracks.
It was concluded that the use of CPP-ACP paste (TM) could remineralize erosive lesions caused by antihistaminic syrup and reduce but not prevent the further effect of erosion with antihistaminic syrup on primary teeth.