الفهرس | Only 14 pages are availabe for public view |
Abstract Background: Blood neutrophil-to-lymphocyte (N/L) ratio and lymphocyte-to-monocyte (L/M) ratio are indicators of the overall inflammatory status of the body, and an alteration in N/L ratio may be found in ulcerative colitis (UC) patients. The aim of this study was to investigate the utility of N/L & L/M ratios as a simple and readily available predictor for clinical disease activity in UC. Methods: 40 patients and 20 healthy individuals served as a control group was enrolled in the study. The neutrophil, lymphocytes and monocyte counts were recorded, and the N/L and L/M ratios were calculated from these parameters. The severity of the disease was based on mayo’s score of classification. Results: N/L ratio was found to be higher in patients with active disease (P < 0.001). The optimum N/L ratio cut-off value for active UC was 2.L/M ratio was found to be lower in patients with active ulcerative colitis, with optimum cut-off value for active UC was 1.65. Conclusion: our results demonstrates that N/L is higher in active UC compared with controls and inactive UC and a cut-off value of 2 can be used to identify patients with active UC. Also it shows that L/M ratio is lower in patients with active UC compared with controls and inactive UC and a cut-off value of 1.65 can be used to identify patients with active UC. |