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Abstract Fiber of cotton plants presented one of the most important production for textiles industries and some medicinal products. The use of IPM applications, can be reduced the chemicals pollutants in the end product of fiber. To evaluate these application, land were prepared using some biological and physical methods. Seeds were treated by different compounds such as imidacloprid, NaCl, KMnO4 or H2O2. Results showed that NaCl done the higher percentage of germination under laboratoty condition, while imidacloprid showed the higher percentage of germination under field conditions. Controlling sucking pests was made by using acetambrid (systemic pesticide). The treatment showed to be efficacies against thrips and jassid under field conditions. The efficacy of some pesticides such as spinetoram (semi-synthetic), chlorpyrifos(organophosphate), emamectin benzoate(avermectin) and methomyl(carbamate) alone or mixed with foliar fertilizer were determined against cotton leafworm and spiny bollworm under laboratory and field conditions. Also, the efficacy of the tested pesticides alone or in mixtures with foliar fertilizer and ethyl alcohol were examined against the different stages of cotton leafworm life cycle ( larval duration, pupal duration, percentages of pupation, percentages of malformed pupae, percentages of emergence and percentages of fecundity). The most effective results were obtained from spinetoram and emamectin benzoate in addition to their mixtures with foliar fertilizer and ethyl alcohol. All tested compounds were examined for their hazard on human health using albino rats as indicators for different parameters (biochemical,. |