الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Diabetic nephropathy (DN) is the most common cause of chronic kidney disease, leading to end-stage renal disease (ESRD) and premature death. Human fetuin A (HFA) plays a prominent pathophysiological role in numerous diseases and pathophysiological conditions with considerable biomedical significance. The present study aims to evaluate the role of fetuin–A in diabetic nephropathy patients under conservative and hemodialysis therapy. The study 80 diabetic patients. They included 40 patients under hemodialysis (GI) and 40 patients under conservative treatment GII.Comparison between the studied groups regarding the laboratory data revealed that GI patients under hemodialysis had significantly higher fetuin A levels when compared with GII patients. Regarding CRP levels, our study found statistically higher levels of CRP and higher frequency of CRP +ve cases in hemodialysis patients when compared with non-hemodialysis patients. Comparison between the studied groups regarding calcium levels revealed significantly lower calcium levels in hemodialysis patients. In the present study, we couldnot detect any significant correlation between fetuin-A levels and clinical and laboratory findings in the studied groups. In the current study, comparison between diabetic patients under HD with diabetic duration less than and more than 15 years showed no statistically significant differences regarding frequency of hypertension, dialysis duration and the other laboratory values including Fetuin-A levels.Comparison between HD patients with dialysis duration less and more than three years in the present study showed that those with high dialysis duration had significantly higher frequency of cases with hypertension.