الفهرس 
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Abstract
Keratocystic odontogenic tumor (KCOT) and ameloblastoma are benign locally aggressive odontogenic tumors with high recurrence rate after surgical removal. Moreover, they are similar in the clinical features. Proliferating cell nuclear antigen (PCNA) is a cell proliferation marker, Receptor activator nuclear factor kappa B (RANK) and RANK ligand play an important role in osteoclastogenesis. The present study aimed to evaluate the immunohistochemical expression of PCNA in KCOT and ameloblastoma, investigate the immunohistochemical expression of RANK and RANKL in both tumors and correlate the immunohistochemical expression of PCNA, RANK and RANKL in KCOT and ameloblastoma.
Material & methods:The immunohistochemical expressions of PCNA, RANK and RANKL were conducted on 40 formalin fixed, paraffin embedded tissue blocks (25 KCOT, 15 ameloblastoma) then The immunoreactivity of PCNA, RANK and RANKL was evaluated by Computer Assisted digital image analysis (Digital morphometric study) and scored according to the statistical percentiles of ameloblastoma group into 4 groups. Results: The statistical analysis revealed that males were more affected than females in KCOT and ameloblastoma with mean age 25.20 ±12.67 in KCOT and 36.27±13.16 in ameloblastoma. The mandible was the most affected site in KCOT and ameloblastoma. Moreover, there was no statistically significant difference between KCOT and ameloblastoma in PCNA, RANK and RANKL expressions. Conclusion: The aggressiveness and the biological behavior of KCOT and ameloblastoma could be predicated from the level of PCNA, RANK and RANKL which were nearly similar.