الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 85 |  |  |
| | | from | 85 | | |
Abstract
The high incidence of varicocele (Vx) among infertile men is associated with impaired semen parameters. A link between Vx and apoptosis was proposed, as many pathways leading to apoptosis are associated with Vx’s negative impact on spermatogenesis; heat stress, androgen deprivation, hypoxia and increased reactive oxygen species.
This study aimed to assess seminal plasma BCl2/Bax in infertile men with Vx.
This study included 111 men that were divided into:
1. Healthy fertile men without Vx (n=20).
2. Fertile men with Vx (n=16).
3. Oligoasthenotertatozoospermic (OAT) men without Vx (n= 29).
4. OAT men with Vx (n= 46).
Exclusion criteria were; subclinical Vx, leukocytospermia, smoking, diabetes, drug therapy. They were subjected to history taking, clinical examination and semen analysis. In their seminal plasma, BCl2 as well as BAX were estimated.
The results showed:
1. There was a significant increase in seminal Bax and significant decrease in seminal Bcl2 in infertile men compared with fertile men being exaggerated in infertile men with Vx.
2. Seminal BAX demonstrated significant negative correlation with sperm concentration, sperm motility and sperm normal forms where seminal Bcl2 demonstrated significant positive correlation with these parameters.
3. Seminal BAX is significantly increased and seminal BCl2 is significantly decreased in men associated with Vx bilateralism and elevated grade.