الفهرس 
Introduction
Chapter (1) : Ambulatory Blood Pressure MonitoringOnly 14 pages are availabe for public view
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Abstract
Hypertension increases the risk for a variety of cardiovascular diseases including stroke, coronary artery disease, heart failure, atrial fibrillation and peripheral vascular disease (Angeli et al., 2014)
Blood pressure (BP) variability (BPV) is a novel risk factor for the development of atherosclerotic diseases. (Lau K-K et al.,2014). and visit-to-visit variability (VVV) of BP is associated with an increased risk for incident coronary heart disease (CHD), stroke, and mortality independent of mean BP (Muntner et al .,2015)
This study included: 220 hypertensive patients who were attendants to Minia University hospital, during the period from May 2015 to May 2016. Patients were newly diagnosed with moderate to severe hypertension (Grade II to III hypertension) i.e >160/100 mmHg or Uncontrolled blood pressure on momnotherapy(>140/90). It was a prospective study carried out in cardiology department at The Minia University Hospital, Egypt.
The aim of this study is to evaluate the effect of combination of (amlodipine and valsartan) versus combination of (bisoprolol and hydrochlorothiazide) on blood pressure variability in patients with moderate to severe hypertension.
All candidates were subjected to the following:
• General examination
• Office blood pressure measurments : according to guidelines of Euroean Society of cardiology.
• Ambulatory blood pressure monitoring (ABPM) was done after controlling of mean blood pressure to calculate blood pressure variability indices Standard Deviation (SD) and Average Reading Variability (ARV).
• Twelve lead ECG .
• Biochemical analysis for Renal function and random blood glucose.
• Complete echocardiographic Assessment
• After the control of BP ,the patients were the followed up for at least 4 weeks.