الفهرس 
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Abstract
Otitis media with effusion is a common pediatric disease. Some causes of OME are viral and bacterial infections, allergies and autoimmune diseases, adenoids, functional abnormality of the Eustachian tube, and gastroesophageal reflux syndrome (Cześnikiewicz, et al., 2004).
Gastroesophageal reflux (GER) is believed to be an important contributing factor for many upper respiratory tract disorders. Relationships between tubotympanic disorder and GER is suggested, but underlying mechanism is unclear. Recently, the role of gastroesophageal reflux and Helicobacter pylori (HP) have been emphasized in the development of OM (Yilmez, et al., 2006)
HP is a helix-shaped gram negative bacterium that cause gastritis, gastric and duodenal ulcers, stomach cancer, and mucosa-associated lymphoid tissue (MALT) lymphoma. HP has been identified in extragastric sites such as tartar, saliva, feces, and in lower parts of the esophagus. Hence, oro-oral, fecal-oral, and gastro-oral routes have been proposed as possible routes of infection.HP is also discovered in adenoid tissue and middle ear fluid, and it has been postulated that HP can be possible cause of chronic otitis media. But the relationship has not yet been confirmed until now (Park et al., 2011).
Aim of our study is to prove that H. pylori may play role in etiopathogenesis of otitis media.
Our study consisted of 80 patients collected from ENT out patient clinic in Minia university hospital. Our patients divided in to two groups:
(1) Recurrent otitis media: fourty patients.
(2) Otitis media with effusion: fourty patients
H. pylori antigen in stool and H. pylori antibody in serum detecting test were done in group (1) we found 6 (15%) positive for H. pylori.
In group (2) antigen in stool, antibody in serum detecting tests and rapid urease test of effusion sample of middle ear were done we found that 27 (67.5%), 21(52.5%), 13(32.5%) positive respectively.
There were significant correlation between three tests.
Our results demonstrate that H. pylori may have role in etio-pathogenesis of otitis media.