الفهرس 
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Abstract
The urokinase plasminogen activator receptor (uPAR) is expressed on most leucocytes including neutrophils, lymphocytes, monocytes, and macrophages which are important in the pathogenesis of sepsis. The interaction of uPAR with its ligand, the urokinase plasminogen activator (uPA), results in numerous immunologic events including cell migration, adhesion, proliferation, and fibrinolysis. After cleavage from the cell surface, the soluble form of uPAR, namely, soluble urokinase plasminogen activator receptor (suPAR), can be found in the blood and other organic fluids in all individuals.
suPAR has been studied in a variety of diseases, suPAR has been suggested as a novel prognostic marker to identify high-risk patients, and may be useful for the clinical management of serious infectious diseases.
The purpose of this prospective study was to evaluate the clinical value of suPAR in the detection of neonatal infection or sepsis and monitoring the responsiveness to treatment.
This study was carried out at the Neonatal Intensive Care Unit of El Minia University hospital. It included 56 neonates (40 of them with suspicion of infection or sepsis and 16 of them were healthy neonate as a control), 2 samples were taken from the patients early just upon first suspicion of infection (on admission) and after 5 days from admission.
Plasma suPAR concentrations were finally measured in 40 infected neonates of mean ± SD gestational age 38.6±0.7 weeks, birth weight 2.8±0.3k g, postnatal age 8.8±4.4 days, and male/female ratio 28/12, and in 16 healthy term infants who had similar gestational age (38.8±0.7weeks), birth weight (3.3±0.4 k g), postnatal age (12.3±6.5days), and gender distribution (10 males, 6 females) to those of infected infants, as controls.
All patients in the study were subjected to adequate history taking, full clinical examination, CBC, CRP with titer, and plasma suPAR level upon suspicion of infection and 5days after admission.
In our study, plasma suPAR was significantly higher in the septic group than the non -infected group at admission and decrease after 5days of admission but still higher than control.
Also, there were significant correlations between plasma suPAR and CRP, I:M ratio, PLT, TLC and Hb in the septic groups.
Our study also found that there was significant difference in plasma suPAR level between survivor and non –survivor patients.