الفهرس 
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Abstract
The aim of this study was to measure serum VEGF level in children with beta thalassemia major as a marker of angiogenesis .
The current study was conducted on 100 children . It included 50 patients with beta- thalassemia major . They were 29 (58%) males and 21 (42%) females aged from 2- 12 years. who presented to pediatric Hematology Clinic, Minia University Hospital during the period from March, 2016 to July, 2016. The study also included 50 apparently healthy children matched for age & sex were included and served as a control group. They were 21 (42%) males and 29 (58%) females aged from 2- 12 years.
All patients were subjected to complete history and full examination.
The following investigations were done:
1- Complete blood count.
2- Serum ferritin.
3- Serum VEGF level.
The study revealed the following results :
The height and weight in patients were lower than in controls (p< 0.001 and p=0.039 respectively). While B.M.I was significantly higher in patients than in controls (p< 0.001).
Patients had significantly lower serum levels of hemoglobin and hematocrite than controls (p< 0.001). While patients had significantly higher serum levels of WBCs, platelets, ferritin and VEGF than controls (p< 0.001).
Serum level of VEGF was significantly higher in splenectomized patients than in non-splenectomized patients (p< 0.001).
Serum level of VEGF was significantly higher in patients with chelation therapy than in patients without chelation therapy (p< 0.001).
A highly significant positive correlation between mean serum VEGF level and age of onset of chelation therapy, platelets, chelation therapy, splenectomy. (r=0.914, r=0.980, r=0.694, r=0.732 respectively) and (p< 0.001 for all).
No significant correlation between mean serum VEGF level and age at diagnosis, age, weight, height, B.M.I, hemoglobin, hematocrite, WBCs, serum ferritin .