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Epidemiology of hepatitis C virus infectionOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) is a progressive disease that may resultin chronic active hepatitis , cirrhosis, and hepatocellular carcinoma. It isestimated that over 200 million people are infected worldwide, while80% develop a chronic form. Egypt has the highest prevalence of hepatitis C virus (HCV) in theworld, estimated nationally at 14.7% . chronichepatitis c virus infection may be associated with many extrahepatic manifestations including cryoglobulinemia, lymphoma,thyroiditisandmembranoproliferative glomerulonephritis. In addition, causal relationship with HCV infection has been suspected for several myocardial impairments including; dilated cardiomyopathy,hypertophic cardiomyopathy and chronic myocarditis . The pathogenesis of these HCV- associated myocardial impairments probably rely on autoimmune phenomena with particular involvement of the human major histocompatibility (MHC) Class II antigen. Troponin I is a sensitive and specific marker of myocardial injury. Elevated troponin levels are associated with a significant increase in morbidity and mortality. So, measurement of troponin I levels may be helpful in patients with chronic hepatitis c virus patients to detect unrecognized myocardial damage . This study carried out on 40 adult patients with chronic hepatitis c virus infection.In addition, twenty healthy control subjects.