الفهرس 
Basal Cell CarcinomaOnly 14 pages are availabe for public view
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Abstract
The BCC and SCC represent the most common malignant neoplasm of the skin. BCC is characterized by local invasion and contiguous spread. SCC is a biologically aggressive tumor and usually metastasize. Following local invasion and tissue destruction, SCC commonly metastasizes to lymph nodes. The CALML3 is an epithelial-specific Ca+2 sensing protein that is highly expressed in tissues and regulated in human keratinocytes during differentiation but downregulated in cancers and transformed cell lines. The CALML3 expression appears to be linked to (terminal) differentiation of skin epithelial cells, with CALML3 levels being up-regulated in suprabasal cells as they migrate toward the upper epidermal layer. The loss of CALML3 expression in epithelial cancers thus likely reflects the transition of tumor cells from a normally differentiating to a poorly differentiated phenotype. So, the aim of this work was to study the immunohistochemical expression of CALML3 in BCC and SCC in a trial to understand its possible role in the pathogenesis of both diseases. This study included 40 subjects classified into 3 groups: group I: included 10 patients and 5 paraffin blocks of BCC. group II: included 3 patients and 12 paraffin blocks of SCC. group III: included 10 normal healthy skin specimens served as control group.