الفهرس 
Polycystic Ovary SyndromeOnly 14 pages are availabe for public view
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Abstract
Introduction:
The prevalence of polycystic ovary syndrome (PCOS) is increasing among the female adolescents and young women. Metabolic disturbances, in particular, insulin resistance (IR) is common in women suffering from PCOS. It has been hypothesized that vitamin D status may contribute to the development of IR in PCOS. This study was designed to investigate the association between vitamin D levels and Insulin resistance along with other characteristics of PCOs.
Methodology:
Eighty-six consenting women with PCO using the Rotterdam criteria [aged 26.67 ± 3.98yr, body mass index (BMI) 26.41 ± 5.64 kg/m2] and eight-six consenting, randomly selected Non-PCO women [aged 28.20 ± 3.30yr, BMI 23.37 ± 3.31 kg/m2] have participated in this study. Participants were identified with IR based on QUICKI and HOMA-IR values, and a total serum 25(OH)D level less than 20 ng/mL was considered vitamin D deficiency (VDD). Anthropometric measurements, and overnight fasting venous samples were collected between the 2nd and 3rd day of menstruation, and analyzed for serum levels of 25-hydroxy-vitamin D (25OHD), fasting blood glucose (FBG), fasting blood insulin (FBI), androgen analogues, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels.
Results:
No between-groups difference was found in the absolute serum 25(OH)D levels (p= 0.135). All PCOS and non-PCOS women were found to have frank VDD (Mean ± SD= 8.07 ± 2.16 and 8.59 ± 2.35 for PCOS and non-PCOS respectively); however lean women had higher 25(OH)D levels than overweight and obese in both PCOS and non-PCOS groups. Vitamin D levels were significantly inversely correlated to BMI, weight, waist and hip circumference in both groups. Apropos the IR link to vitamin D status, no statistically significant differences were found in 25(OH)D levels between IR and non-IR women in both groups (p= 0.378, p= 0.115 for PCOS and non-PCOS women respectively). Also, no significant correlations were found between vitamin D levels and QUICKI and/or HOMA-IR in this study.
Conclusion:
Although PCOS women and controls had different metabolic profiles, insulin resistance was not a predictive factor of vitamin D status. No differences in the absolute level of serum vitamin D or prevalence of VDD were detected between women with PCOS and weight-matched controls. Our results confirm the absence of link between vitamin D status and insulin resistance in PCOS women and controls.