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Abstract Septic shock is the most severe form of sepsis and is one of the most significant causes of death among critically ill patients. Sepsis-induced myocardial dysfunction SIMD is one of the major predictors of morbidity and mortality in sepsis; characterized with left ventricular dilation, depressed ejection fraction, and recovery within 10–7 days. Mitral annular plane systolic excursion MAPSE has been proposed as useful echocardiographic parameter for the assessment of LV longitudinal function and correlates with global systolic function of the LV; being the earliest marker of myocardial injury and dysfunction and easily obtained even for the untrained observer and in patients with poor acoustic windows. MAPSE value is thought to be an independent tool for LV systolic function assessment generally, as well as myocardial injury in patients with sepsis induced myocardial dysfunction, and also a predictor of mortality in patients with severe sepsis and septic shock. To test this, MAPSE, LVEF, and SOFA score were measured in 50 septic shock patients (of whom 28 were survivors and 22 were non-survivors). It was found that there was statistically significant negative correlation between SOFA scores levels (mortality predictor) with MAPSE values among group I survived patients (average; r – 0.95 with p-value <0.001), and the same results were shown among group II non-survivor patients (average; r – 0.85 & 0.84 with pvalue <0.001), with high percentage of non-survivor group had MAPSE ˂ 9 mm, on the other hand high percentage of survivor group had MAPSE ≥ 9 mm. and regarding ROC curves |