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Abstract Although currently available medications, combined with psychotherapy, permit 75-80% of patients with BAD to lead an essentially normal life, long-term adherence to prescribed treatment is difficult to sustain in BPD patients, especially during periods of relative euthymia or euphoria. Non-adherence to medication regimens rates range from 15% to 85% in medical illnesses, It is frequently reported for bipolar patients, with an incidence ranging from 20% to 60%. It is a frequent feature among euthymic bipolar patients, with a rate of 40%. Bipolar disorder (BD) is responsive to a number of evidence-based foundational medication treatments, including lithium, some of the anticonvulsant mood-stabilizing medications, and antipsychotic drugs, particularly second-generation compounds. Several pharmacological treatment strategies have been proposed for relapse prevention in patients with bipolar disorder such as mood stabilizers and, according to more recent guidelines, second-generation antipsychotics. |