الفهرس 
PsoriasisOnly 14 pages are availabe for public view
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Abstract
Psoriasis is a hyper-proliferative inflammatory skin disease, characterized by the presence of erythematous skin lesions with adherent silvery scales (psoriatic plaques). It ranges in severity from a few scattered erythematous, scaly plaques to involvement of almost the entire body surface. Psoriasis patients have a natural history of outbreaks (flares) followed by temporary remissions. Environmental factors can trigger or exacerbate flares. These factors include; Infection, Trauma, Stressful life events, Obesity, Smoking and Drugs. Prolactin (PRL) is a hormone, mainly produced in anterior pitutary gland, although it can be produced in extra-pitutary sites. It has been hypothesized that PRL may modulate the skin immune system and may be involved in the pathogenesis of psoriasis. Functional PRL receptors are detected on epidermal keratinocytes and PRL effectively increased the in vitro growth of keratinocytes in psoriasis. Dopamine agonist therapy is recommended to lower PRL level. Cabergoline in preference to other dopamine agonists because it has higher efficacy in normalizing PRL levels. The aim of work was to evaluate the clinical efficacy of Cabergoline (as a prolactin lowering drug) in the treatment of psoriatic patients with hyper-prolactinemia.