الفهرس 
KI-67 as a Proliferation MarkerOnly 14 pages are availabe for public view
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Abstract
Introduction: Acute leukemia is clonal neoplastic proliferation of immature hematopoietic cells in the bone marrow or blood. These immature hematopoietic cells or blasts accumulate in the bone marrow and fail to differentiate into normal, mature blood cells. It comprises two types, acute lymphocytic leukemia and acute myelogenous leukemia. (AML) is group of clonal diseases with transformation of an early myeloid precursor.
Aims: The aim of this work is to measure the plasma level of the proliferation marker ki-67 in acute leukemia patients who undergo hematopoietic stem cell transplantation correlating this finding with other clinical and lab data and to assess its clinical & prognostic value in such patients.
Methodology: The current study included forty adult patients, with acute leukemia (myeloid and lymphoblastic) with allogeneic hematopoeitic stem cell transplantation in the period between: July 2013 and March, 2015 at either Ain Shams university hospital or Nasser Institute BMT units.
Results: The current study included forty adult patients, with acute leukemia (myeloid, lymphoblastic and biphenotypic leukemia) with allogeneic hematopoeitic stem cell transplantation in the period between July, 2013 and March, 2015 at either Ain Shams university hospital or Nasser Institute BMT units. They were 26 males (65%) and 14 females (35%). Their age ranged between 20 and 52 with a median age of 30 years. Their diagnoses were 26 cases AML (65%), 12 cases ALL (30%), 2 case biphenotypic leukemia (5%). 8 cases were transplanted at Ain shams university hospital BMT unit (20%) and 32 cases at Nassir Institute BMT unit (80%).
Conclusions: In conclusion we found statistically significant positive correlation between plasma Ki67 level before and after transplantation & the day of engraftment, incidence of acute GVHD, incidence and duration of neutropenic fever. Patients who developed graft failure had also significant higher Ki-67 level after SCT.
Recommendations: Additional studies on large number of cases in association with assessment of prognostic role of circulating Ki 67 level on the outcome of allogeneic HSCT in different hematologic malignancies.