الفهرس 
Ischemic Heart DiseaseOnly 14 pages are availabe for public view
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Abstract
Background: IHD is one of the commonest causes of morbidity and mortality. Atherosclerosis is the basis of CAD; it results in asymmetrical thickening of the arterial wall. Nitric oxide plays an important role in prevention of atherosclerosis. Many studies were interested in studying the association between G894T gene polymorphism and IHD.
Objectives: To determine the association between G894T gene polymorphism and IHD among smokers.
Methods: 80 subjects were included (40 IHD cases and 40 controls). Demographic and clinical data were collected for both groups (age, history of DM, history of HT, family history of IHD). Real time PCR reaction was used to determine the gene polymorphism.
Results: Both descriptive and analytical statistics were done. There was no statistically significant difference between cases and controls regarding the genotype and allelic frequency.
Conclusion: eNOS G894T gene polymorphism doesn’t increase risk of IHD among smokers according to our results.
Key words: Ischemic heart disease, endothelial nitric oxide, gene polymorphism, smoking, G894T gene polymorphism .