الفهرس 
Down Syndrome OverviewOnly 14 pages are availabe for public view
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Abstract
Introduction: Down Syndrome (DS) results from trisomy of human chromosome 21which determines among other characteristics mental and growth retardation. DS has an annual incidence of 1/800 living birth worldwide. Approximately 40% of children with DS have congenital cardiopathies. It is extremely important to develop nutritional assessment studies which will provide health care professionals with suitable tools and information that can adapt to features of their target population. Such studies can be done through anthropometric measurements, biochemical tests, clinical and dietary assessment.
Objective: The aim of the study is to evaluate the effects of congenital heart diseases on the nutritional status of patients with Down syndrome.
Patients and methods The study will include 80 patients of Down syndrome with and without associated congenital heart diseases aged from 6 months till 5 years taking into consideration the two variables to be equally represented. Patients will be recruited from both pediatric cardiology and genetics specialized clinics at Ain Shams University Children’s Hospital. They were subjected to a full history with special emphasis on the cardiac symptoms and a detailed dietetic history (Food frequency questionnaire and 24 h dietary recall), Anthropometric measurements, complete blood count.
Results: Nutritional assessment of DS patients with CHD(group I) and DS without CHD (group II) showed that ignificant difference as regard to height, weight, head circumference, arm circumference, anthropometric indictors in terms of z-score, mean values of the dietary intake of energy and macronutrients and micronutrients which were higher in group II rather than group I. The results showed that group I had statistically significant higher mean total leucocytes count compared to group II but no significant difference between both groups as regard to the other blood indices. Also the results showed that statistically significant difference between complicated and non complicated groups as regard weight, weight for age (in terms of z-score) which were higher in non complicated compared to complicated group.
Conclusion: Our data confirm that Down patients DS with congenital heart disease CHD have higher risk of developing underweight, stunting and wasting compared to DS patients without CHD.