الفهرس 
Bronchial asthmaOnly 14 pages are availabe for public view
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Abstract
Asthma is a chronic inflammatory airway disease characterized by cough, chest
tightness and wheezing, and it is associated with reversible or variable airway
obstruction. However, the diagnosis and follow-up of the disease are currently based
on symptoms and lung function measurements rather than on assessing the underlying
inflammatory process.
Several asthmatic phenotypes with different inflammatory mechanisms have
been described suggesting that asthma is not a single disease entity but a syndrome
with different underlying causes and mechanisms.
Adipokines like leptin, adiponectin, resistin and adipsin are protein mediators
secreted by adipocytes and macrophages within the adipose tissue .
Leptin levels increase in obesity and leptin has therefore been suggested to
belong to the factors explaining the relation between obesity and asthma.
There are only few publications on resistin in human asthma with conflicting
results. Larochelle et al found higher resistin levels in asthmatics and the levels were
increased with disease severity, while Kim et al suggested that resistin may have a
protective effect against asthma.
The aim of the present study was to evaluate the level of resistin in adult
asthmatic patients and its potential relationship with asthma severity.
This study was conducted in the chest and medical biochemistry departments
of Menoufia University Hospitals and Mahalla Chest Hospital. The study included 50
subjects their ages ranged from 19-58 years.
It included, 40 adult asthmatic patients and 10 healthy age and sex matched
controls. The asthmatic patients were grouped as follows: group (A) asthma in
between attacks and group (B) asthma exacerbation, that was subdivided into
group(I), (II)and (III) mild, moderate and severe asthma exacerbation respectively.
After obtaining an informed consent all subjects were subjected to the following:
History taking.
Clinical examination (general and local).
Plain chest x-ray (postero-anterior view).
Complete blood counting.
Liver function tests.
Kidney function tests.
Random blood sugar.
Pulmonary function tests.
Assay of serum resistin level by ELISA kit.
In this study, serum resistin was not significantly higher in asthmatics than
non-asthmatics. However, obese asthmatics had the highest resistin levels.