الفهرس 
OBESITY, TYPE 2 DIABETES MELLITUS ANDOnly 14 pages are availabe for public view
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Abstract
Type 2 diabetes mellitus (T2DM) is a heterogeneous group of metabolic disorders caused by the interaction between genetic predisposition and environmental factors. The incidence of T2DM has increased over the last decades, with more than 170 million individuals suffering from T2DM all over the world, which imposes a great economic impact on individuals, families, and health systems.
Though the genetic susceptibility to T2DM is polygenic, single nucleotide polymorphisms (SNP) at the transcription factor 7-like 2 gene (TCF7L2) have been strongly associated with T2D risk in various populations and ethnic groups.
Type 2 diabetes is reported to be associated with a systemic low-grade inflammation as indicated by increased levels of circulating acute-phase proteins like CRP and of IL-6. These changes were found to be associated with patients with impaired glucose tolerance (IGT) as well, which suggest a role of these mediators in the pathogenesis of type 2 diabetes.
The aim of the study was to explore the relation of TCF7L2 gene polymorphism, inflammatory status, the disease control parameters, and the dietary habit of the diabetic patients of type 2. We also aimed to explore the relation of the genetic variants and the dietary parameters in the patients’ relatives and compare the results to those of the patients