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Abstract Anaesthetists are often faced with the question of the risks of regional anaesthetic techniques when performed on patients receiving anti-thrombotic medications which can be classified into: antiplatelet, anticoagulant and fibrinolytic drugs. This is not only because the popularity of regional anaesthesia is on the rise but also because the use of anti-thrombotic drugs in the prevention of venous thromboembolism is expanding. The decision of regional anaesthesia always requires a careful risk–benefit analysis and the perioperative cessation of anti-thrombotic drugs to improve the safety of regional block needs to be critically evaluated. The vascular injury during regional anaesthesia in patients with anti-thrombotic therapy is the main and major complication that causes haematoma at the site of injury compressing important organs and structure. So, each group of these drugs has its perioperative anaesthetic recommendations and management. Conclusion: Highlights on the perioperative guidelines were described by many societies like the American Society of Regional Anesthesia and pain medicine (ASRA) and European Society of Regional Anaesthesia and pain therapy (ESRA) to decrease the complications of regional anesthesia in those taking anti-thrombotic drugs. |