الفهرس 
Hepatitis C VirusOnly 14 pages are availabe for public view
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Abstract
Background: After discovery of the hepatitis C virus (HCV) more than 20 years ago, HCV infection has become a global problem that requires active interventions for prevention and control. There is a significant association between chronic hepatitis C infection and the development of cirrhosis and hepatocellular carcinoma worldwide. Epidemiological studies estimate that 130-170 million persons or 2-3% of the world population are infected with HCV. Egypt has the greatest burden of HCV infection in the Middle East, where 15% of the population are infected with HCV where HCV geneotype-4 (HCV-4) represents 90% of infected cases.
Aims: The aim of this study is to determine the association between TLR7 (rs179008 gene) polymorphism and (Chronic hepatitis C infection with and without Hepatocellular Carcinoma).
Methodology: The present study was conducted on 59 patients suffering from HCV and HCC and 21 sex and age matched healthy controls. Among the 59 patients, 33 were men and 26 women. Their ages ranged from 28 to 67 years.
Results: This study was conducted on 59 patients diagnosed as chronic HCV infection (group 1). It divided into 29 patients with chronic hepatitis C virus infection not associated with hepatocellular carcinoma, 17 males and 12 females (group 1a). Thirty patients with chronic hepatitis C virus infection associated with hepatocellular carcinoma 16 males and 14 females (group 1b). Twenty one age and sex matched apparently healthy volunteers with no history of liver disease as a control group (group 2). Eleven females and 10 males.
Conclusions: This study shows that (AT) genotype is significantly higher in female HCC group compared to control group. These patients could then be subjected to a more careful or earlier routine screening for HCC.
Recommendations: Considering detection of TLR7 gene polymorphism as a screening marker to detect patients with an increased risk to develop HCV and HCC.