الفهرس 
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Abstract
Zinc Oxide Nanoparticles (ZnO-NPs) are among those most widely manufactured on a global scale. They play an important role in a very wide range of applications, ranging from tyres to ceramics, from pharmaceuticals to agriculture and from paints to chemicals.
The nanoparticles have different physical and chemical properties compared to their conventional bulk counterparts, even if they are of the same composition, which might alter their bioactivity. Their ability to induce toxicity has been attributed to their increased surface reactivity. The smaller the particles are, the more surface they have per unit mass and the more reactive they are in the cellular environment.
Investigating the potential hazardous effect of ZnO-NPs on the liver of adult male albino rats has been a point of interest in the recent research work, as it is well documented that, after their injection or ingestion, ZnO-NPs are able to deposit and bio-accumulate in the liver tissue.
Oxidative stress has been suggested to be the main mechanism of toxicity caused by the NPs including the ZnO ones.
The aim of the present work was to investigate the possible cumulative functional and histological impact on adult male albino rats after long term daily oral administration of zinc oxide nanoparticles in a dose resembling the average environmental exposure.
The ZnO-NPs were synthesized by hydrothermal method and characterized by using the TEM, zeta potential measurement and X-Ray diffractometer.