الفهرس 
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Abstract
The present work was performed to study the hematotoxic, hepatotoxic and genotoxic effects of carbendazim (CBZ) and /or mancozeb (MNZ) as environmental pollutants in female rats. Moreover, the ameliorative hepato-protective and geno-protective effects of Nigella sativa oil (NSO) as antioxidant agent in both fungicides intoxicated rats.
One hundred and twenty adult female Sprague-Dawley rats were divided randomly into 8 equal groups. group (1): Kept as normal control.group (2): Rats orally received CBZ using a stomach tube at a dose level of 200 mg/kg b. wt daily for continuous 2 weeks. group (3): Rats orally received MNZ using a stomach tube at a dose level of 1/10 LD50 (300 mg/kg b. wt) daily for 2 continuous weeks.group (4): Rats orally received both CBZ and MNZ with the same dose and duration as in groups(2 and 3).group (5): Rats orally received NSO using a stomach tube at a dose level of 2ml/kg b. wt daily for continuous 2 weeks.group (6): Rats orally received NSO as in group (5) for 2 weeks followed by CBZ as in group (2) for another 2 weeks.group (7): Rats orally received NSO as in group (5) for 2 weeks followed by MNZ as in group (3) for another 2 weeks. group (8): Rats orally received NSO as in group (5) for 2 weeks followed by both CBZ and MNZ as in group (4) for another 2 weeks. All groups were left untreated for further period of 15 days to observe the withdrawal effect. After 2 weeks from starting the treatment and after another 2 weeks from the.