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العنوان
Pattern of risk factors and management strategies in patients with acute coronary syndrome, in different age groups and sex category /
المؤلف
Hussein, Ahmed Nader Taha.
هيئة الاعداد
باحث / أحمد نادر طه حسين
مشرف / أحمد أشرف رضا
مناقش / مراد بشاي مينا
مناقش / أحمد أشرف رضا
الموضوع
Coronary heart disease - Chemotherapy.
تاريخ النشر
2017.
عدد الصفحات
199 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض القلب والطب القلب والأوعية الدموية
تاريخ الإجازة
1/2/2017
مكان الإجازة
جامعة المنوفية - كلية الطب - أمراض القلب والأوعية الدموية
الفهرس
Only 14 pages are availabe for public view

from 199

from 199

Abstract

Acute coronary syndrome (ACS) refers to a spectrum of clinical presentations ranging from those for ST-segment elevation myocardial infarction (STEMI) to presentations found in non–ST-segment elevation myocardial infarction (NSTEMI) or in unstable angina. It is almost always associated with rupture of an atherosclerotic plaque and partial or complete thrombosis of the infarct-related artery.(1)
Acute coronary syndrome (ACS), the acute manifestation of ischemic heart disease, remains a major cause of morbidity and mortality worldwide and is responsible for more than 1 million hospital admissions in the United States annually. Considerable research is being conducted in the field. This review provides a contemporary overview of key new findings on the pathophysiology, diagnosis, treatment, and prognosis of ACS. (4)
Some risk factors—such as age; cigarette smoking; high blood pressure; elevated levels of LDL cholesterol, low levels of HDL cholesterol, family history of premature CHD, and high fasting plasma glucose levels—are epidemiologically strongly associated with CHD, even though the precise mechanism by which they promote atherosclerosis and predispose a person to CHD is not fully understood.(3)
The present study involves studying of the pattern of these risk factors and its difference among age groups and sex category from which we found the following Regarding the relation between the gender and age in the studied groups this difference was statistically non-significant (p- value >0.05).
 Regarding prevalence of positive family history had the highest prevalence among the oldest age group and decreased with age.
 Regarding prevalence of diabetes mellitus and hypertension among age groups was of higher prevalence among the age groups 3 & 4 and it was lower in group 1.
 Regarding levels of lipid profile, for cholesterol levels the highest levels were in group 2 and 3, while group 1 and 4 had the lowest levels, for triglycerides levels the highest levels were in group 1 and 4, while group 2 and 3 had the lowest levels, for HDL levels had the highest levels was in group 4 and lowest level was in group 1. Finally for LDL levels the highest levels was in group 1and the lowest levels was in group 2.
 Regarding prevalence of obesity had the highest prevalence among group 3 and the lowest prevalence in group 1.
 Regarding Current cigarette was more prevalent in the youngest age groups and decreased in older age groups to reach the lowest level in the oldest group.
 Regarding Patient’s presentation group1 had the highest percent of STEMI patients and group 4 had the lowest percent, while the percent of NSTEMI/UA was higher among older age groups.
 The incidence of in hospital complications and mortality rate was higher among the oldest age groups with deceased incidence among the youngest one, as we had found that the occurrence of heart failure, acute MR, AF increases with age advancement
 Females have a higher incidence of HTN and +VE family history, more atherogenic lipid profile pattern and high BMI than males. There was significant difference between males and females as regard DM, HTN and cigarette smoking.
 Diabetic patients have significantly higher prevalence of abnormal levels of TCh, LDL, TGS, obesity and central obesity than non- diabetics. The mean value of lipid profile, BMI and waist circumference was higher in diabetic patients than non-diabetics.
 Hypertensive patients have significantly higher prevalence of abnormal levels of TCh, LDL, TGS, obesity and central obesity than non- hypertensive, Also the mean value of lipid profile, BMI and waist circumference was higher in hypertensive patients than non- hypertensive patients.