الفهرس 
review of literatureOnly 14 pages are availabe for public view
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Abstract
Hcv infection is a common health problem worldwide. The world health organization estimates that up to 3% of the global population is infected with hcv. Egypt has the highest prevalence of hcv in the world. Over 70% of individuales acutely infected with hcv develop chronic infection at significant risk of progressive liver fibrosis and subsequent liver cirrhosis and hepatocellular carcinoma .
liver fibrosis is the excessive accumulation of extracellular matrix proteins and is considered as a a wound healing reasponse to chronic liver injury. Accurate assessment of liver fibrosis has become increasingly important in order to make therapeutic decisions, determine prognosis and to follow-up disease progression. Liver biopsy is the gold standard for diagnosing and staging liver fibrosis, but it is invasive and suffers from several limitations. There is an urgent need for a less invasive method than biopsy and this led to this led to the development of non- invasive methods.
Serum markers of liver fibrosis offer an attractive, cost effective, cost effective alternative to liver biopsy for both patients and clinicians. Non- invasive fibrosis offer markers can be classified as direct , indirect, and imaging methods. Indirect markers reflect alterations function, direct markers reflect extracellular matrix turnover.
The present study aimed to identification of serum cytokeratin-1 (ck1) as a fibrosis marker in patients with chc using western blotting technique, as well as the detection and quantification of serum ck1 using ELISA and studing the correlation between the ck1 level and differentstages of liver fibrosis. In addition, we evaluated as a marker of fibrosis in patients with CHC.
In the present study: blood samples from 212 CHC patients with liver fibrosis associated with hcv, positive for anti-hcv antibodies, patients were than confirmed for the presence of HCV-RNA using polymers chain reaction assay, were collected from Mansoura university hospitals, Mansoura,Egypt.