الفهرس | Only 14 pages are availabe for public view |
Abstract Helicobacter pylori infection has a wide spread distribution, but the prevalence varies between developed and developing countries Infection is usually acquired during childhood. To define the epidemiological character of a disease, one needs a diagnostic test that is inexpensive, reliable and readily available across a broad spectrum of population. The development of new noninvasive reliable serological tests has opened the door for epidemiological exploration. The objective of this study was to determine the seroprevalence of H. pylori infection among apparently healthy Egyptian children living in qulubia governorate and belonging to various social classes, also to assess the risk factors influencing the prevalence of Helicobacter Pylori infection, and to study the effect of H. pylori on growth of the studied cases. A Series of four hundered (400) apparently healthy children Attending basic schools were included in our study, were assayed for the presence of Anti- Helicobacter pylori antibody (IgG) measured by enzyme linked immunsorbant microassayed test (ELISA) and studied for the effect of age, sex socioeconomic background and other risk factors who influencing the prevalence of H. pylori infection. Their ages ranging from 6years to 13 years. Serum Samples were withdrawn from the above cases and assayed for the presence of Anti- Helicobacter pylori antibody. It was observed that the overall H. Pylori seroprevalence in cases of the study were 44% (176/400) and frequency of seropositive cases increased highly significantly with advances of age. In trial to study risk factors for acquisition of H. Pylori infection in our cases group, we found a highly significant difference between seropositive and seronegative cases regarding (Socioeconomic status, breastfeeding cases, duration of breastfeeding, educational status of parents, Family history of gastric troubles and cases who had not owned domestic animals). On the other hand, we found no significant differences between seropositive and seronegative cases regarding (Sex, water supply, different blood groups) Regarding occupatinal status of parents, we found that H. pylori prevalence was highly significant higher among cases of farmers than among cases of blue collar and white collar workers; moreover cases living in white collar families had a lower risk of being positive for H. pylori infection. Studying dietary factors, we found that high salty foods intake were highly statistically significant risk factor, also there was significant difference regarding high fruits, Vegetables and high milk intake while there was no significant difference regarding (, fish, chicken, been, rice and cheese) intake. In trial to study effect of H. pylori on growth, we found only a significant difference in height between infected and non-infected children in those cases older than 6 years to 9years compared to the other age groups where no significant difference in stature was found between infected and non-infected cases. Moreover, significant difference in the centile value for weight was detected between infected and non-infected cases among the two age groups. |