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Abstract Introduction: Trauma is the leading cause of death between 1 and 45 years of age and is responsible for numerous definitive handicaps and high costs. Head injuries are among the most common types of trauma encountered in emergency departments (EDs) and intensive care units. Aims: The aim of the work is to evaluate the role of sedative drugs in management of patient with severe traumatic brain injury and prevention of secondary traumatic brain injury in intensive care unit. Methodology: Trauma is the third leading cause of death overall and the leading cause of death among those aged 1–44 years. TBI is a major public health Problem due to the fact that each year, an estimated 1.5 million people sustain head injury in the United States. Conclusion: Sedative agents have adverse effects of on airway patency, respiratory function, and hemodynamic balance. Adverse events during procedural sedation may be prevented by the appropriate pre-sedation evaluation of the patient, intraprocedural monitoring of physiologic function, and early intervention when adverse effects are recognized. |