الفهرس 
Lichen Planus
Possible target antigens:Only 14 pages are availabe for public view
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Abstract
Lichen planus is a chronic mucocutaneous inflammatory disease that affects skin, mucous membranes, scalp, and nails. The exact pathogenesis of the disease remains unclear but cell-mediated cytotoxicity is regarded as a major mechanism of pathogenesis of LP. Activated T-cells release cytokines leading to attraction of inflammatory cells and destruction of keratinocytes.There are many evidences that refer to the important role of NK cells in the pathogenesis of several autoimmune diseases,due to their cytotoxic activity and the release of pro inflammatory cytokines. They are now seen not only as bona fide actors in innate immunity but also as important cells that shape and influence adaptive immune responses and are more and more being endorsed with an immunoregulatory role. However, NK cells are not a homogeneous cell population and several subtypes exist in human blood NK cell subpopulations can be defined on the basis of the relative expression of the markers CD16 &CD56. The aim of this work was to evaluate the expression of CD56 CD16 NK cells in cutaneous lichen planus to assess its possible role in the pathogenesis of lichen planus. The present study was carried out on 20 patients with LP with different clinical varieties. They were collected from the Outpatient Clinic of Dermatology and Venereology Department,Tanta University Hospitals during the period from August 2014 to October 2015.