الفهرس 
Helicobacter PyloriInfectionOnly 14 pages are availabe for public view
 |  | from | 188 |  |  |
| | | from | 188 | | |
Abstract
Introduction: Helicobacter pylori infection is associated with severe gastrointestinal pathologies. Moreover, it may causes an extra intestinal diseases such as, insulin resistance, atherosclerosis and autoimmune diseases. Fetuin A play a major role in the association between H. pylori infection and insulin resistance.
Aim of work: the aim of this study is to detect serum fetuin A and to evaluate its role as a possible link between Helicobacter pylori infection and insulin resistance.
Methods: sixty patients complaining of dyspepsia was selected for this cross sectional study .The patients were divided into two groups with matching age, sex and the basic laboratory investigations results. group (A) patients were Helicobacter pylori-positive. group (B) patients were Helicobacter pylori negative based on endoscopic findings and confirmed by histopathological diagnosis and exclusion of other causes of dyspepsia. Homeostasis model assessment (HOMA- IR) was used to asses Insulin resistance then compared between the two groups. Also, serum fetuin A was measured then compared between the two groups
Results: in the present study, there was a highly statistical significant difference between H. pylori positive group and H. pylori negative group as regard HOMA- IR ( p value : 0.001). also , there was a highly statistical significant difference between H. pylori positive group and H. pylori negative group as regard serum fetuin A (p value > 0.001).
Conclusion: there is an association between H. pylori infection and insulin resistance. So, H. pylori infection is a risk factor in developing insulin resistance. Moreover, serum fetuin A play a major role in this association as it is considered as the link between H. pylori infection and insulin resistance.