Search In this Thesis
   Search In this Thesis  
العنوان
THE SIGNIFICANCE OF VON WILLEBRAND FACTOR LEVEL IN HCV PATIENTS RELATED chrONIC LIVER DISEASE WITH AND WITHOUT HEPATOCELLULAR CARCINOMA/
المؤلف
Hassan,Ahmed Gad Dandarawy .
هيئة الاعداد
باحث / أحمد جاد دندراوى حسن
مشرف / سيد محمد شلبى
مشرف / راوية عبد السلام الفقى
مشرف / وسام أحمد إبراهيم
تاريخ النشر
2013.
عدد الصفحات
150.p;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب الباطني
تاريخ الإجازة
1/1/2013
مكان الإجازة
جامعة عين شمس - كلية الطب - Internal Medicine
الفهرس
Only 14 pages are availabe for public view

from 150

from 150

Abstract

C
omparison of Von Willebrand factor antigen (vWF-Ag) in peripheral blood samples in the 3 groups by ELISA method and found significant rise in its level in group B than group A and significant rise in group C than group B and A.
There was a highly negative correlation between serum Von Willebrand factor antigen (vWF-Ag) and albumin, Hb, PLT, while it was highly positive with S.bilirubin, INR, ALT and no correlation with AST and WBCs.
On the other hand, deterioration of liver function and worsening of liver laboratory parameters always accompanied with increased levels of serum (vWF-Ag).
So, the conclusion is that there was a relationship between plasma levels of Von Willebrand Factor (vWF) in patients with CLD at different stages of the disease and it correlates with the severity of disease.
Moreover there was obvious relationship between plasma level of vWF-Ag and HCC, this could be proved through the Rock curve with sensitivity of 96.4%, specificity of 96.6% and accuracy of 96.5% and also through the logistic regression analysis that showed that vWF had a highly statistically significance as a predictor for HCC .