الفهرس | Only 14 pages are availabe for public view |
Abstract Rosacea is a chronic inflammatory disease of the skin. It affects up to 15% of the general population with the highest prevalence among adults, mostly in females with fair skin. Symptoms present in various combinations and degrees of severity, often fluctuating between periods of exacerbation and remission. The complex network of the pathophysiology of Rosacea is still unclear however, it is thought that Inflammatory mediators from an altered innate immune response plays a crucial role in its pathogenesis via the cathelicidin and/or serine protease pathways. Existing therapies only temporarily improve cutaneous symptoms but are not curative. Traditionally, Rosacea is considered a disease that is limited to the skin. A few studies have observed higher risk of cardiovascular risk factors including dyslipidemia, hypertension, hyperglycemia and high CRP titre. Furthermore, they are at increased risk of CAD. Although, the mechanism underlying this increased risk is precisely unknown, it was thought that increased atherosclerotic risk in rosacea patients might be also related to innate immune system dysfunction via the cathelicidin and/or serine protease pathways.This study included 50 randomly selected Rosacea patients of different clinical subtypes and 50 control subjects; age and gender matched with our cases. Full history was taken, general and local examination including; subtype and severity evaluation, weight, height, BMI, waist circumference, blood pressure were measured. Investigation including, total lipid profile, fasting blood sugar and CRP titre. All cases and controls were assessed and diagnosis of metabolic syndrome was made according to ATP III criteria. Statistical analysis revealed a statistically significant increase in risks of high cholesterol, triglycerides, LDL, fasting blood glucose and low HDL in patients of rosacea in comparison with healthy controls, however; there was no significant difference in cases and controls as regard the waist circumference, the BMI, the blood pressure and the CRP titre. After implication of ATP III criteria in cases and controls it revealed that there was a highly significant difference between cases and controls as regard incidence of metabolic syndrome with higher values in cases than controls. Incidence of metabolic syndrome was significantly high in moderate to severe grade of rosacea versus mild grades of rosacea. There were no significant difference in incidence of metabolic syndrome in relation to Rosacea subtype and disease duration.We suggest that rosacea patients are at increased risk of developing cardio-vascular risk factors and are accordingly more liabe to have metabolic syndrome and that moderate to severe grade of Rosacea patients are more suceptable to have metabolic syndrome. |