الفهرس 
Introduction and review of literatureOnly 14 pages are availabe for public view
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Abstract
This study was aimed at detecting the diagnostic performance of CBCT in the diagnosis of arthritic changes induced in rats’ condyles using a comparison of CBCT findings with the histological one “gold standard”.
Forty rats divided into control and study groups were examined by CBCT and histolgical analysis. Arthritis was induced in a study group of 20 rats using CFA injection where CBCT results were compared to the histological results. Bone density values of the study group were examined also by CBCT and histolgical analysis then values were correlated to each other.
The current study revealed a statistically significant difference between CBCT and histological findings. Nevertheless, they were totally matching in condylar erosion findings. Furthermore, the significant difference in condylar flattening was in favor of CBCT as it couldn’t be detected histologically at all. In addition, the detected synovial proliferation was a histological result only, thus not affecting CBCT diagnostic performance
Therefore, this study confirmed a high diagnostic performance of CBCT based on; the recorded accuracy was 95.29%, the sensitivity was 93% and the specificity was 100%. Moreover, the NPV was 86% and the PPV was 100%. However, the small sized rats’ condyles and their unfamiliar anatomy decreased the reliability of the different observers’ readings.
On comparing bone density values between study and control groups by histological image analysis and by CBCT voxel value measurements, the comparison confirmed a significant decrease in values of study group due to CFA injection. On the other hand, the correlation of CBCT-VV to the histological bone density values of the study group was not statistically significant though it was a positive one.
from the current study it can be concluded that:
1. High diagnostic performance of CBCT.
2. 3D imaging of CBCT was superior in the detection of condylar flattening than plain histological sections.
3. Insufficient correlation of CBCT-VV to the histological values of bone density measurements.