الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Carcinoma of unknown primary is one of the most rarely diagnosed cancer worldwide and represents less than 2% of all cancer deaths.
The present work was carried out to review medical records of all patients diagnosed with Carcinoma of unknown primary and to identify the incidence of cases presenting to Alexandria main university hospital, stand on treatment modalities applied and survival outcomes.
To achieve this aim, the present study included 428 patients diagnosed with Carcinoma of unknown primary. Those patients presented to Clinical Oncology and Nuclear Medicine Department, Alexandria Main University Hospital between January 2003 and December 2012. Medical records of the included patients were reviewed. Epidemiological data, clinicopathological data and details of various administered treatment regimens were retrieved and tabulated. Overall survival (OS) and progression free survival (PFS) of patients who were managed at our department were estimated using Kaplan-meier method.
Age at presentation ranged between 20-81 years and most of the patients was above 40 years {88.6%}.
The symptoms at presentation was varied very widely according to involved site; lung, bone, brain, lymph nodes, others.
Only 329 patients had applicable files to be enrolled in the study to complete our assessment of treatment results.
A wide variety of Pathology types was distributed as Adenocarcinomas with highest percentage 48.9% was 161 case, Poorly differentiated carcinoma, Squamous cell cancer, Poorly differentiated malignant neoplasm, Neuroendocrine carcinoma.
Age, Gender, residence, family history, smoking, involving site, Pathological subtype, Therapeutic Modalities and added palliative radiotherapy were tested in relation to survival Analysis.
Age, Gender,, smoking, involving site, Pathological subtype, Therapeutic Modalities and palliative radiotherapy showed statistical association with PFS and OS.
Chemotherapy was the mainstay of treatment according to site and type of pathology which suggested a possible original site and best OS and PFS was recorded in the combination regimens, some patients received palliative radiotherapy which also increased OS and PFS.
Missing data was a major problem during our study analysis .More attention should be given for data registry