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Abstract ascites is observed in 5%-10% of advanced cirrhosis, and has a one year mortality rate of 20-50%. Liver transplantation is the only definitive treatment for these patients, but the procedure is limited by shortage of liver donor resources and its high cost. Repeated large-volume paracentesis with intravenous albumin infusion was considered as first option to treat refractory ascites however LVP may be associated with many adverse effects, transjugular intrahepatic portosystemic shunt (TIPS) has been recently reported to be an effective treatment for refractory ascites however the few randomized controlled trials comparing TIPS with LVP gave a controversial results especially regarding survival, therefore this study was conducted on Egyptian cohort with refractory ascites to evaluate the efficacy and safety of TIPS versus large volume paracentesis in the treatment of refractory ascites. |