الفهرس 
Pathophysiology of Gastrointestinal Stromal Tumors (GISTs)Only 14 pages are availabe for public view
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Abstract
Background: Gastrointestinal stromal tumors (GISTs) are uncommon tumors of the GI tract with an estimated unadjusted incidence of around 1/100 000 / year (Nilsson et al., 2005). However, GISTs are the most common mesenchymal tumor of the gastrointestinal tract (80%). It represent about 1-3% of all gastrointestinal malignancies.
Aim of the Work: This essay aims to review recent advances in diagnosis and management of Gastro intestinal stromal tumors (GISTs).
Methodology: Gastrointestinal stromal tumors (GISTs) are uncommon tumors of the GI tract with an estimated unadjusted incidence of around 1/100 000 / year. However, GISTs are the most common mesenchymal tumor of the gastrointestinal tract (80%). It represent about 1-3% of all gastrointestinal malignancies.
Conclusion: GISTs can be lethal; five-year survival depends on tumor size, mitotic index and location. The median overall survival is 14 years or higher for patients with an intermediate or lower-risk of malignant behaviour, whereas the median overall survival is only 1.5–3.4 years for patients with a high-risk for malignant behaviour. The estimated number of persons at high-risk for malignant behaviour was about 5-6 persons per million per year in The Netherlands. The true number may be higher, because the metastatic risk could not be assessed in part of the patients with a biopsy.
Keywords: Gastro Intestinal, Stromal Tumors