الفهرس 
Pathophysiology, predisposing factors & Clinical picture of skin lesions of different endocrine diseasesOnly 14 pages are availabe for public view
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Abstract
Introduction: The skin often signals systemic changes. Some neoplastic diseases that affect internal organs may trigger several cutaneous manifestations. Endocrine pathology associated with skin diseases include: thyrotoxicosis; hypothyroidism; Cushing syndrome; Addison disease; acromegaly; hyperandrogenism; hypopituitarism; primary hyperparathyroidism; hypoparathyroidism; and manifestations of diabetes mellitus.
Aim of work: To put spot light on skin lesions related to endocrinal surgical diseases regarding early detection and management of these lesions.
Methodology: Endocrine pathology associated with skin diseases include: thyrotoxicosis; hypothyroidism; Cushing syndrome; Addison disease; acromegaly; hyper-androgenism; hypopituitarism; primary hyper-parathyroidism; hypoparathyroidism; and manifestations of diabetes mellitus.
Conclusion:
Merkel cell carcinoma (MCC) is a deadly disease with a poor outlook for survival. Local recurrence occurs in 44% of patients; multiple local recurrences occur in 15%. These recurrences usually happen within 5 months after the primary lesion is treated. About 15% of patients have palpable nodes at the time of diagnosis. Lymph node metastases eventually develop in 55% of patients, and distant metastases develop in 34%. Most metastases occur before the eighth month after diagnosis. The areas where metastases are most likely to occur are the liver, bone, brain, and lung. The presence of distant metastases is the only factor that is consistently predictive of the outcome.