الفهرس 
Introduction and aim of work:Only 14 pages are availabe for public view
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Abstract
Acute leukemia is pathologically defined as blast cell neoplasia or malignancy of immature hernatopoietic cells. Unregulated clonal proliferation of hematopoietic stem cells in the bone marrow leads to the production of immature and abnormally functioning cells that fail to differentiate normally but are capable of further division. These leukemic cells accumulate in the marrow, suppressing the proliferation and differentiation of normal hematopoietic cells, leading to the most important manifestations of this disease, namely anemia, hemorrhage and infection.
The role of DNA methylation 111 tumor genesis has attracted considerable attention recently, as most human neoplasms appear to have an imbalance in DNA methylation patterns, including global • loss of
DNA methylation or increased levels of methyl transferase enzyme or regional increase in CAN methylation often involving promoters of
selected genes.
Keywords: Cell cycle - Genetic aberrations and oncogenesis - Acute leukemia - Methylation specific PCR.