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Abstract Reaction of quinazoline with chloroacetonitril and potassium carbonate anhydrous in the presence of DMF was stirred for 13 h to afford2-[4-oxoquinazolin 3(4H)-yl]acetonitrile (2)in 70% yield A solution of 2 and hydrazine hydrate in ethanol was reflux for 5 h to afford 2-[4-Oxoquinazolin-3(4H)-yl]acetimidohydrazide (3)in 43.5% yield A mixture of 2with sodium azide and ammonium chloride in the presence of DMF was reflux for 7 h to afford 3-[(2H-tetrazol-5-yl)methyl]quinazolin-4(3H)-one (4)in 84.5% yield A mixture of 3 with triethyl ortho formate in ethanol was refluxed for 24 h to afford 3[(1H1,2,4triazol3yl)methyl]quinazolin-4(3H)-one (5)in 45 % yield |